Tepezza Side Effects
Generic name: teprotumumab
Note: This document contains side effect information about teprotumumab. Some dosage forms listed on this page may not apply to the brand name Tepezza.
Applies to teprotumumab: intravenous powder for solution.
Serious side effects of Tepezza
Along with its needed effects, teprotumumab (the active ingredient contained in Tepezza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking teprotumumab:
More common
- Blurred vision
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- nausea
- stomach pain
- sweating
- trouble breathing
- unexplained weight loss
- unusual tiredness or weakness
- vomiting
Less common
- Fast, pounding, or irregular heartbeat or pulse
- feeling hot
- headache
- muscle pain
Incidence not known
- Bleeding from the rectum
- diarrhea that may contain blood
- severe stomach pain
Other side effects of Tepezza
Some side effects of teprotumumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Change or loss of hearing
- change or loss of taste
- dry skin
- hair loss or thinning of the hair
- mild diarrhea
- muscle spasms
- unusual tiredness or weakness
Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Applies to teprotumumab: intravenous powder for injection.
Musculoskeletal
Very common (10% or more): Muscle spasms (25%)[Ref]
Gastrointestinal
Very common (10% or more): Nausea (17%), diarrhea (12%)
Common (1% to 10%): Dysgeusia
Frequency not reported: Exacerbation of inflammatory bowel disease[Ref]
Metabolic
Very common (10% or more): Hyperglycemia (10%)[Ref]
Nervous system
Common (1% to 10%): Headache[Ref]
Dermatologic
Very common (10% or more): Alopecia (13%)
Common (1% to 10%): Dry skin[Ref]
Other
Very common (10% or more): Fatigue (12%), hearing impairment (10%)
Common (1% to 10%): Infusion reactions (transient blood pressure increases, feeling hot, tachycardia, dyspnea, headache, and muscle pain)[Ref]
Frequently asked questions
- What are monoclonal antibodies?
- How does it work, what's the mechanism of action?
- Tepezza before and after, what should I expect?
- How long does Tepezza stay in your system?
- Is Tepezza a chemotherapy drug?
- How long does it take to work?
- Is Tepezza used to treat Graves disease?
- Tepezza and COVID vaccine, what should I know?
- Can Tepezza treat eye bulging and double vision?
More about Tepezza (teprotumumab)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (4)
- Drug images
- Dosage information
- During pregnancy
- Support group
- FDA approval history
- Drug class: growth hormone receptor blockers
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
References
1. (2020) "Product Information. Tepezza (teprotumumab)." Horizon Therapeutics USA Inc
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.